We are living longer, and 75 is not the ripe old age it used to be. But it’s a cutoff age for PSA screening – and this is missing cancer in men who really need to be treated, say Brady investigators. “There is increasing evidence that this age-based approach is significantly flawed,” says Johns Hopkins urologist Patrick C. Walsh, M.D. Walsh and I have written several books on prostate cancer, and this new information is being added to the upcoming 4th edition of our book, Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer, which we’re writing now.
Walsh is the senior author of a recent Johns Hopkins study that looked at high-risk prostate cancer in older men.The study’s interdisciplinary group of investigators also includes first authors Jeffrey Tosoian andRidwan Alam, and Carol Gergis; Amol Narang, Noura Radwan, Scott Robertson, Todd McNutt, Ashley Ross, Danny Song, Theodore Deweese, and Phuoc Tran.
The U.S. Preventive Services Task Force recommends against screening for men over 75.“There’s no question that there has been overtreatment of prostate cancer,” says urologist Tosoian. “However, that is getting better; more men are taking part in active surveillance programs, and we are much better at interpreting PSA and other biomarkers to rule out aggressive disease.”
But PSA can’t be interpreted if a man doesn’t get his PSA tested.Population studies have shown that “men diagnosed at 75 years or older account for 48 percent of metastatic cancers and 53 percent of prostate cancer deaths, despite representing only 26 percent of the overall population,” says Tran, clinical director of Radiation Oncology and Molecular Radiation Sciences at Hopkins.
Why are older men more likely to die from prostate cancer?To find out, the team studied 274 men over age 75 who underwent radiation therapy for prostate cancer. “We found that men who underwent PSA testing were significantly less likely to be diagnosed with high-risk prostate cancer, and that men with either no PSA testing or incomplete testing (either a change in PSA was not followed up, or a biopsy was not performed when it was indicated); had more than a three-fold higher risk of having high-risk disease at diagnosis, when adjusted for other clinical risk factors,” says Tran.
Although this was a small study and more research is needed, Walsh says, “we believe that PSA screening should be considered in very healthy older men.”
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
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If your mom had breast cancer, that could raise your risk for prostate cancer. If you have aggressive prostate cancer, your daughter might be at higher risk for ovarian or breast cancer. Some “bad apple” genes run in families; doctors know what they are, and there’s a blood test to look for them.
For the last two decades or so, doctors and scientists have talked a lot about genes and genetic testing, and about gene-fixing medicines that can stop cancer in its tracks. Until recently, with a few exceptions, that’s mostly what it has been: talk, and frankly, a fair amount of hype.
That’s changing.I recently interviewed Jonathan Simons, M.D., medical oncologist and molecular biologist, and also President and CEO of the Prostate Cancer Foundation, which has funded some of the most exciting research in this area. “Everybody talks about genes,” he says.“But what really matters is, how does it help you?How can it help your children and grandchildren?”
A new blood test called the Cascade Genetic Test looks for mutations in several known “bad apple” genes.These are genes that are supposed to repair DNA damage. When they malfunction, it is easier for cancer to develop.
What does this mean to you?Well, say you’re a man with a rising PSA, and a biopsy shows just a small amount of low-grade cancer.Your doctor might want to wait and do another biopsy in six months to a year, and you might decide to get yet another biopsy a few months after that.But what if you could add a very important piece of extra knowledge to the puzzle?What if you could find out whether you have one of these bad genes?That might lead you to seek treatment right away, before the cancer has a chance to get established outside the prostate.
Another thing: “If a man tests positive for one of these genes, his sisters, brothers, and children will need genetic testing, as well, because of the high probability that their cancer risk has been significantly elevated,” says Simons.“Men on active surveillance should have these genes tested.”
Very important: Testing positive is not a cause for alarm, or for making panicky, hasty decisions.“Genes don’t have to be your destiny,” notes Simons.
In other words, if you have one or more of these genetic mutations, cancer is not a done deal.But it’s on the table.
A man diagnosed with prostate cancer who has one of these mutated genes needs to take that cancer diagnosis very seriously, even if it seems to be low-level, “safe” prostate cancer.
It turns out that more than half of American men are carrying a gene that they inherited from either their mother or their father that increases their chances of getting prostate cancer.“We now know that prostate cancer is perhaps the most heritable of all the major cancers,” says Simons.Again, having one of these bad genes doesn’t mean that cancer is inevitable – which also means that having a healthy diet and lifestyle may help prevent cancer from ever getting started – but it can make it easier for cancer to spread and become difficult to treat.
“The genes tell their story,” says Simons.The good news is that, for the first time, a test can provide the Cliff’s Notes preview of what that story might be. For more on this test, keep reading.
Bad “Spell-checker” Genes
An important study, led by Fred Hutchinson Cancer Research Center medical oncologist Peter Nelson, M.D., funded in part by the Prostate Cancer Foundation, and published in the New England Journal of Medicine, is changing how we think about prostate cancer. What Nelson has found can be summed up like this:
Prostate cancer is a lot more of an inherited disease than anybody thought;
There are 16 bad genes that we now know to look for; and
If you have a mutation in one of these genes, your sons and daughters, and their children need to know about it, because they are more likely to develop cancer, too.
Every gene has a job.Some of them act like brakes that control cell growth; some do just the opposite, and instead of curbing growth, they step on the accelerator and speed it up in a bad way.Some genes are tiny Xerox machines, making genetic copies.And some genes are little quality control specialists; they’re the spell checkers.
The genetic mutations we are born with are called germline mutations.Those are different from the kind of incremental gene mutations that develop over time – through exposure to carcinogens in cigarettes, for example, or eating a bad diet, or drinking too much alcohol.
Nelson’s study looked at these inherited mutations in 20 spell-checker, or “DNA-repair,” genes, in 692 men with metastatic prostate cancer at institutions in the U.S. and United Kingdom.They found mutations in 16 of them, including some unexpected ones, like BRCA1 and BRCA2.
“Now wait,” you may be thinking, “aren’t they the breast cancer genes?”Yes, and for years, these genes were not significantly linked to prostate cancer.Now we know that the very same mutation that can cause breast and ovarian cancer in women can cause lethal prostate cancer in men.
Other bad DNA-repair genes include one that sounds like it should be at a bank, called ATM; and one that sounds like a roadie making sure the microphones work at a concert, called CHEK2; there’s RAD51D; and one that sounds friendly but isn’t at all, called PALB2, which is strongly involved in pancreatic and breast cancer.
These gene mutations are rare in the general population, but startlingly common in men with metastatic prostate cancer:Because of this work, Nelson and colleagues estimate that one in nine – 12 percent – of men with metastatic cancer have them, even if they have no family history of prostate, breast, or ovarian cancer.
And this last part is actually hopeful because it means that cancer is not inevitable if you carry one of these mutations.It may well be that if you live your life doing some things that we know help prevent or delay prostate cancer – not eating a lot of red meat and dairy products, eating foods like broccoli and tomatoes, not smoking, not drinking an excessive amount of alcohol, and not being overweight, which adds stress to your cells and makes them less resistant to cancer – that you will never develop prostate cancer.And if you start getting screened for prostate cancer at age 40, and if you are then screened every year to look for changes in your PSA and other markers, that if you do develop cancer, it will be caught early and you will be cured.
So don’t despair.But if you have metastatic prostate cancer, Nelson recommends that you get genetic testing, because your kids and grandkids need to know if one of these bad genes runs in the family – so they can be considered high-risk for certain types of cancer, screened vigilantly, treated aggressively if cancer is found, and most important of all, live to a ripe old age and not die of cancer.
Other hopeful news:There are entirely new kinds of cancer-fighting drugs that target specific genes.One class of drugs is known as PARP inhibitors, and the standout in this class is Olaparib, which is being used to treat women with BRCA mutations in ovarian cancer.It has now been approved as a treatment for advanced prostate cancer in some men.
What should you do?If you have high-risk or metastatic prostate cancer, or if you have a strong family history of prostate or other cancers, ask your doctor about this test. It costs $250 at Color Genomics.
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
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“There’s no one way to select candidates for active surveillance,” says urologist and molecular biologist Chris Barbieri, M.D., Ph.D., of Weill Cornell Medical College/New York Presbyterian Hospital. In addition to doing molecular research on prostate cancer, he treats men with all kinds of prostate cancer and works with several hundred patients currently on active surveillance.
Some hospitals have very specific criteria.For example, at Johns Hopkins, men selected for the active surveillance program are considered “very low-risk.”These men have Gleason score 6 cancer in no more than two biopsy cores; in each of these cores, cancer is present in half or less; their PSA density (PSA divided by prostate volume; this can be helpful if a man has benign prostate enlargement, or BPH, which is a separate prostate problem and is not cancer) is 0.15 or less; and they have no cancer that can be felt on a rectal exam.Other men in the Hopkins program have “low-risk” cancer: no cancer that can be felt on a rectal exam, a PSA below 10, and Gleason 6 cancer on their biopsy.All men are monitored faithfully, with regular follow-up visits and yearly biopsies, although recent studies suggest that some men can still be safely monitored with a longer interval between biopsies.
Other hospitals take it more on a case-by-case basis.The truth, says Barbieri, is that “nobody knows the perfect way to do this.There are many hospitals where physicians are taking very reasonable approaches,” even if they differ on the exact specifics.“The principle is that it’s for men with a low volume of disease, and a low grade of cancer.”However, he adds, the National Comprehensive Cancer Network’s newest guidelines, unanimously developed by a panel of the country’s top urologists and scientists, has stated that selected patients with Gleason 3 plus 4 disease can also be considered for active surveillance.“Age comes into play,” he says, as does the man’s general health.
How often should men on active surveillance get repeat biopsies?“There’s no formal consensus,” says Barbieri.“Quite frankly, we as a field are still trying to figure out how to do this perfectly, what’s working best and what’s not working.”Although some men on active surveillance decide to have the cancer treated just because they’re anxious about it, “I think that’s improving, as we get the message out that some prostate cancers clearly are never going to threaten a man’s health during his natural lifetime.The diagnosis itself becomes a little less threatening.”There has been a major shift in attitude, he adds.“More men are open to active surveillance, and are comfortable with the idea of watching the cancer instead of treating it right away.”
If there is going to be a “grade reclassification” – if a repeat biopsy finds a greater volume or a higher grade of cancer – it usually happens within the first two years.“For most active surveillance protocols, the definition for when a cancer has progressed is based on a change in the grade,” says Barbieri.“So if you had a Gleason 3 plus 3 cancer, and we find a higher grade of cancer with another biopsy, you are considered to have progressed on active surveillance, and most experts would suggest treatment.”
Thus, a change in the grade of cancer can be a game-changer (meaning you go from being on active surveillance to needing treatment).So is a change in the volume of disease.“If a man has two cores of his initial biopsy positive for cancer, and the next time, 6 or 8 cores are positive, that’s a lot more cancer there,” and this likely needs to be treated.
What about the risks from having a lot of repeat biopsies?“The major risk is the risk of infection,” Barbieri explains.“The current data suggest the risk is between 2 and 5 percent per biopsy.If you roll the dice enough times, you’re more likely to get an infection.”The risk can be minimized in several ways, including prescribing different antibiotics after each biopsy (to help avoid resistance to the drugs), and doing a rectal culture to determine the presence of certain bacteria, and selecting antibiotics based on that.Other risks, besides infection, include having trouble urinating after a biopsy and – this is a very small risk – the risk of excessive bleeding that requires a transfusion.
What questions should you ask your urologist about active surveillance?
Here are a few that Barbieri suggests:
Does my cancer need to be treated now?
Given my age and general health, is this a good treatment for me?If you are a young man, perhaps in your early fifties, you may decide to get your cancer treated, so you don’t have to think about it anymore, Barbieri says.
Should I get a second opinion on my biopsy? Most likely yes, says Barbieri.“In my experience, it is very rarely a bad idea to get a second opinion.”
You may also be wondering:When can I safely stop active surveillance?The answer there is, “We don’t know yet when it’s safe to stop active surveillance.”
What about red flags from the doctor’s perspective?Even if a man seems to have low-grade, low-risk, low-volume cancer, are there reasons why active surveillance is not for him?“I don’t think I would deny any man the opportunity to be on active surveillance if he understands the risks.” says Barbieri.
However:If you are a man of African descent, you are at a higher risk to have prostate cancer, a higher risk to have more aggressive prostate cancer, and at a higher risk to die of prostate cancer if you do have it.Even if it seems to be the “good” kind. You can still be on active surveillance, but careful urologists such as Barbieri will keep an especially close eye on you.“I’m more likely to order additional tests for African American men,” including an MRI and genetic tests.“Most small or even medium-sized cancers really can’t be seen on transrectal ultrasound.MRI can show this.It can give you a lot of information about the location of a possible tumor, and whether the tumor is higher-grade.”However, MRI is more expensive; it also can generate false positives and lead to additional biopsies.
Another red flag for Barbieri is the man’s family history.“If somebody looks like he should be fine on active surveillance and has a bunch of prostate cancer in his family, that’s reasonable as long as you’re keeping a close eye on him.”However, he is concerned “if a man’s family members died of prostate cancer, especially at a fairly young age.I always ask that question: what happened with the prostate cancer?If your dad had it and died at age 60, that’s a different situation than, say, your dad got it at age 78 and got hit by a bus at age 97.”When the family history has men dying of prostate cancer, this suggests that a different kind of cancer – the opposite of indolent; in fact, aggressive enough to kill – may be a possibility.
And the presence of Gleason 4 disease makes Barbieri wary.“Gleason 4 plus 3 disease and above, or any young man with any Gleason pattern 4.”The presence of Gleason 4, especially in a younger man, suggests that the cancer may be more aggressive than it seems and that it probably needs treatment.
Finally, what about red flags from the patient’s perspective?What should a doctor not be doing?Beware of over-frequent biopsies, says Barbieri.“If a doctor is doing biopsies more often than in the range of consensus, after a first confirmatory biopsy to know there wasn’t high-grade cancer missed – doing it more than yearly is hard to justify.”Also, beware of a doctor who orders lots of tests and can’t really give you a good explanation for why you need them.For example, “frequent transrectal ultrasound on active surveillance doesn’t really help” do anything except pad the doctor’s bottom line, rather than serve the patient’s best interests.
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
https://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.png00Janethttps://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.pngJanet2016-11-21 10:26:062019-06-21 09:47:30Active Surveillance for Prostate Cancer: Questions to Ask
Is active surveillance right for you?The answer to this question varies, depending on a bunch of factors: your particular form of prostate cancer, your age, and general health, and also on the criteria used to select men for active surveillance programs from hospital to hospital; some are stricter than others.
Men who are eligible for active surveillance have cancer that shows all signs of being the “good” kind:slow-growing, low-volume (meaning, there’s not very much of it in all the tissue samples from your prostate biopsy), not aggressive.
Can men live with slow-growing, low-volume prostate cancer?Absolutely.The proof of this is found every day, in many thousands of autopsies done around the world, of men in their eighties and older who died of something else – a heart attack, for instance.Then, in the autopsy, the pathologist looks at the man’s prostate and sees cancer in there. This cancer is what doctors call “indolent.”It’s low-risk.Slow-growing, low-volume. It sits there.It doesn’t cause any harm, and clearly never needed to be treated, because the guy never knew he had it and died of something else.When urologist Christopher Barbieri, M.D., Ph.D., on the faculty at Weill Cornell Medicine at New York Presbyterian, talks to his patients who are candidates for active surveillance, he tells them, “You’re more likely to get hit by a bus when you’re 100 years old than for this cancer to kill you.”
Let us digress for a moment and think of prostate cancer in the form of an animal.The most aggressive cancer is like a bird; it grows quickly and is very likely to fly away from the prostate to other places in the body, making it more difficult to kill.The least aggressive cancer moves like – well, something slow, a turtle, or a sloth.And then there are men with the cancers in between – let’s think of them as rabbits — cancers that do need to be treated with surgery or radiation.
Indolent prostate cancer is the pet rock of cancers; it doesn’t do much, but the upside of that is that it doesn’t need to be treated, either.
Important point:Cancer may not stay indolent.Or, from the initial biopsy and test results it might appear to be low-risk and or low-volume, but actually more cancer is there and the biopsy needle just missed it.So, men who choose active surveillance may not stay on it forever if their cancer undergoes “grade reclassification” – if that is, you have another biopsy and it suggests that more cancer is present, or that it may not be so slothlike in personality.So if you choose active surveillance, know that at some point, you may need to have surgery or radiation. If you are an African American man, talk to your doctor about getting an MRI to make sure that you don’t have cancer that was missed on the biopsy.
Choosing active surveillance – remember the keyword is “active” – means that you will need to keep getting your cancer checked out.You will need to get follow-up PSA tests, exams, and biopsies, maybe once a year, for many years.If you are a young man, say age 50, and you could reasonably expect to live another 40 years, this could mean that you get your prostate stuck with needles many, many more times in your life.(Not until you’re 90, but at least another 15 years or so.)Biopsies have their own risks, which I’ve written about here.You may not want to subject yourself to this.
You will also have to live your life knowing you have cancer.Can you handle this?Some men can’t.Thinking about the cancer in there makes them anxious.To them, it’s like a time bomb – when actually, it may not be a time bomb at all, but more of a clock just happily ticking away, not causing harm – and they end up having surgery or radiation just for the peace of mind.
On the other hand, if you can live with it — trusting that the follow-up monitoring will detect any change if it happens and that if you need to get treatment, you won’t miss that window of treatment when the cancer is still confined to the prostate, and you will have plenty of time to make that decision — then active surveillance may be a good option for you.
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
https://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.png00Janethttps://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.pngJanet2016-11-18 10:16:072019-06-21 09:45:02Active Surveillance for Prostate Cancer
You’ve had the PSA test – or more likely, several of them – plus the digital rectal exam, and one or both of these suggested that you needed a biopsy.The biopsy was not fun, but you did it, and then you waited for a pathologist to look at the tiny, needle-sized cores of tissue removed from your prostate.Maybe you managed to forget about it while you were waiting – maybe you feel perfectly healthy, and this all seemed surreal.Or maybe you let some dark thoughts creep in, and you started thinking about cancer and remembering everyone you ever know who has had cancer and not done very well.The waiting’s over now.Your doctor has just given you the news:there’s cancer in there. What are you going to do?
The very first thing you should do is, don’t panic.
If you have cancer in your prostate, it didn’t just spring up like a mushroom.It has been there for years, maybe even a decade, growing very slowly, taking a long time just to get big enough to be discovered. “Even in a fairly aggressive form, prostate cancer grows slowly compared to other cancers,” says urologist and molecular biologist Christopher E. Barbieri, M.D., Ph.D., on the faculty Weill Cornell Medicine at New York Presbyterian. I recently interviewed him for the Prostate Cancer Foundation’s website.
What this means for you is: brush the dark thoughts away.Nobody wants to have cancer, but if you have to have it, there has never been a time of more hope.There have never been better treatments.There have never been so many men not dying of prostate cancer, and not having bad side effects from treatment.
You are going to get through this.
If your cancer was diagnosed through regular screening, that’s an extra reason to be upbeat:Just a couple of decades ago, before the PSA test and regular screening became widespread, most men didn’t know they had prostate cancer until it was often too late.Either it had gotten advanced enough to cause symptoms like back pain or urinary problems, or it was big enough for a doctor to feel it during a rectal exam.Many men used to be diagnosed when cancer was no longer confined to the prostate and was more difficult to treat.
That’s no longer the case.Thanks to regular screening, most men are diagnosed at least five years earlier than they used to be.Most men are diagnosed with cancer that is very curable.In fact, many men are diagnosed with cancer that maybe shouldn’t even have been found – cancer that doctors call “incidental,” which means it’s just there, but it doesn’t do anything.It just sits there in your prostate, just a few very slow-growing, not aggressive cancer cells, and you could have lived your whole life never knowing they were in there.Many men die with prostate cancer, not of it.
So the second thing you need to do – the first, remember, is do not panic – is figure out just what kind of prostate cancer you have.
If you were diagnosed at a smaller medical center, doctor’s office, or hospital, it’s a good idea to have your biopsy results sent out to another pathologist at a large medical center, where they see a lot of men with prostate cancer, for a second opinion.Prostate cancer can be tricky to interpret, and it’s a good idea to get a second opinion from somebody who specializes in looking at it – not breast cancer, not ovarian cancer, not colon cancer, just prostate cancer.
The third thing:Take your time.
Once you know what you’re dealing with, your first reaction should not be, “Oh, my God! I’ve got to get this out of here!” or other words to that effect.Do not feel rushed to get treatment right away.First of all, your body needs several weeks to heal from the biopsy.Second, now is the time – for you to figure out which treatment is right for you.
Remember, that cancer has been in there for a long time.It’s not going to grow very much over the next few weeks; in fact, it may not grow at all.If you and your doctor decide you need surgery or radiation to kill the cancer you then need to find the best place – it may be nearby, or in another city in your state, or even further away – for you to have this done.It is far better to take a little while – not much time at all in the greater picture of your life – and make a decision that is right for you than to rush into treatment and later regret being so hasty.
Do not despair.Take heart, take a deep breath, and figure this thing out. You are not alone.There are millions of us here in the “reluctant brotherhood” of prostate cancer (and plenty of sisters, too – wives, daughters, sisters, girlfriends, mothers – who have shared this journey).Reach out to us.We have been where you are now, and come through it.You will, too.
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
Good news for people who love barbecue, hot dogs, burgers, and steak cooked on the grill: It pays to eat your veggies.
The key to this story is something called “PhIP.” A few years ago, noted Johns Hopkins scientist Bill Nelson, M.D., Ph.D., director of the Sidney Kimmel
Comprehensive Cancer Center, began investigating its role in cancer. PhIP is a funny little word. (Pronounced “fipp,” it’s a short name for a long chemical
compound.) It sounds so harmless: “Hey, let’s get PhIP and go over to the club for some tennis,” or “I don’t give a PhIP what you do,” or “Let’s do some
PhIP shots!” But it’s not.
PhIP is found in meats cooked at high temperatures. It is a “pro-carcinogen,” a chemical that turns into something that can attack and mutate DNA, and is
known to cause prostate, breast, and colorectal cancer in rats. Unfortunately, we create carcinogens, or cancer-causing agents, with every steak we grill
or piece of chicken we fry, and PhIP is one of them. In 2007, Nelson and pathologist Angelo De Marzo, M.D., Ph.D., reported in Cancer Research
that when rats are exposed to PhIP, DNA mutations occur in the prostate. Since then, they have learned much more about this little sucker’s role as a
dietary contributor to cancer. I recently wrote about Nelson’s work for Discovery, the research magazine for the Brady Urological Institute at Johns
Hopkins.
The scientists have discovered that veggies help counteract the effects of PhIP. “When we fed rats tomato and broccoli along
with PhIP, the animals lived longer and showed reduced incidence and severity of prostate neoplasms (new, abnormal cell growth; particularly of PIN,
prostatic intraepithelial neoplasia – funny-looking cells that are linked to prostate cancer), intestinal cancers and skin cancers as compared to rats fed
PhIP alone,” says Nelson. “This provides even more evidence that eating vegetables may protect against cancer-causing agents like those in overcooked
meats.”
There is a twist to the story: Food safety pays off, too.
Nelson, along with De Marzo and scientist Karen Sfanos, Ph.D., has also explored the idea that prostate cancer may involve a combination of “environmental insults” – bad things in the diet, plus something else that weakens the body, like an infection. They wondered whether chronic inflammation, caused by bacterial infection, would make a difference in rats that had consumed PhIP. Using a specific strain of E.coli isolated from a patient with chronic prostatitis/chronic pelvic pain syndrome, they found to their surprise that the charred food plus the nasty bug seemed to have a systemic effect.
Together, E.coli and PhIP caused an increase in the development and progression of cancer in the skin and digestive tract. (Note: many people have E.coli in their gut and it is harmless, but some strains can get into meat when it’s processed and can survive if the meat is undercooked.) The rats that received the double punch of E.coli plus PhIP fared worse than rats that ate the PhIP alone. In one study, the bacteria- and PhIP-consuming rats developed more precancerous lesions within the prostate and might have developed even more problems – except they also died sooner.
In further experiments, they found that “when we inoculated PhIP-fed rats with E.coli in the prostate, the animals developed acute and chronic
prostate inflammation out of proportion to that seen with PhIP ingestion or E.coli inoculation alone, and had more prostate neoplasms, intestinal
cancers, and skin cancers,” says Nelson. “This hints that prostate infections and dietary carcinogens might interact to promote chronic prostate
inflammation and prostate cancers, and that prostate infections might augment carcinogen effects on other tissues, as well.”
What does this mean for you? One, that if these things cause changes in the prostate, it’s a pretty good bet that they are hurting you elsewhere, as well,
so take precautions: eat a veggie in addition to a potato. Potatoes are delicious, but they don’t help fight cancer the way green, leafy vegetables and
tomatoes do. Two, tomatoes and broccoli probably aren’t the only vegetables that can help diffuse the bad effects of charred meat; these are just the ones
that were studied in this particular investigation. Three, don’t eat undercooked meat. You’re not just risking food poisoning, which comes in like a
freight train and goes away quickly; you may be adding to your risk of developing cancer.
Nelson, along with De Marzo, Sfanos, and Hopkins colleagues recently published two papers on these striking new findings in the journals PLoS ONE
and Cancer Prevention Research.
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
https://vitaljake.com/wp-content/uploads/2015/10/300_200_grilled_veggie.jpg201300Janethttps://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.pngJanet2015-10-15 07:50:252018-09-30 16:40:15Charred Food Bad, Veggies Good for the Prostate
“Hey, buddy! It’s me, your prostate. How’s it going? I know you’re busy, but … I’m just going to put it out there. You’re ignoring me. You never call, you don’t even text — and you don’t get me checked.”
Okay, that wasn’t actually your prostate, but let’s face it, for most men the prostate is not a top health priority.It falls in the category of “obscure body parts” that includes the spleen, the medulla oblongata, and the little thing that hangs at the back of your throat.
Most men reckon that the prostate is best dealt with on a need-to-know basis.Unfortunately, you will need to know about the prostate sometime, because this troublesome gland is the source of three of the major health problems that affect men:Prostate cancer, the most common major cancer in men; benign enlargement of the prostate (BPH, for benign prostatic hyperplasia), one of the most common benign tumors and a source of urinary symptoms for most men as they age; and prostatitis, painful inflammation of the prostate, the most common cause of urinary tract infections in men. Some men are unlucky enough to deal with more than one of these over the course of their lifetime.
Today, I want to talk to you about prostate cancer.Because when it’s caught early, it is usually curable.Equally important:In its earliest, most curable stages, prostate cancer produces no symptoms and you feel perfectly fine.The best way to not die of prostate cancer is to find it when it’s still curable.As Patrick Walsh, M.D., the great Johns Hopkins urologist and my longtime co-author, puts it, “If you can expect to live at least 10 to 20 more years and don’t want to die from prostate cancer, you should be screened.”
Start When You’re 40
Screening involves two things:A blood test for PSA (prostate-specific antigen) and a digital rectal exam that takes about a minute.You should start when you’re 40, and depending on your results, you may not even need to get screened every year.The PSA test is like a barometer for the prostate – but it’s best served up as a continuum, not a cut-and-dried, one-shot reading.Another Johns Hopkins urologist, H. Ballentine (Bal) Carter, M.D., came up with a concept called PSA velocity. Years ago, using an excellent database called the Baltimore Longitudinal Study of Aging (BLSA), he was able to look at the blood of men over a period of many years.He looked at their PSA levels, and watched as they changed, or didn’t change, over time. He has published many articles on this, and Patrick Walsh and I have written about it in several books (most recently, the Third Edition of Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer, which has everything you could possibly want to know about PSA and the many ways to test it.)
Here’s the most basic information you need to know:
Get the Test
If you are in your forties, and you have a PSA level greater than 0.6 ng/ml (nanograms per milliliter), you should get your PSA measured every year.
If you are in your fifties, and your PSA is greater than 0.7, you should get your PSA measured every year.(These numbers come from Carter’s research. In another study, urologists Stacy Loeb, now at New York University, and William Catalona of Northwestern University, found the numbers to be slightly higher; 0.7 for men in their forties and 0.9 for men in their fifties.)
This first PSA test is your baseline.From this, your doctor will watch your PSA to see if it changes.If you have a low PSA level (between 1 and 4 ng/ml), any increase is alarming.In a study using data from the BLSA, Bal Carter and colleagues found that if PSA climbs more than 0.2-0.4 ng/ml per year, this is a predictor of death from prostate cancer.This is really important: No matter what your number is, if it keeps going up, you need to have it checked out. Especially if you are in a high-risk group for prostate cancer — if you have a family history of the disease, or if you are an African American.The number shouldn’t be changing very much.If it is changing, and you don’t have a good reason for it (like a urinary tract or prostate infection; see below) you need to get a biopsy.If no cancer is found and it’s still going up, you need to get a repeat biopsy in several months.(There are other reasons why PSA can go up, including BPH, but this is more common in men in their sixties and older.For men with a PSA greater than 4, an average, consistent increase of more than 0.75 ng/ml over the course of three tests is significant.)
Now, as I write this, I have a friend with a family history of prostate cancer; his father, uncle, and grandfather have all had it.He is 51.His PSA has gone up more than 0.2 ng/ml each year over the last two years.His urologist has not recommended a biopsy.In my opinion, his urologist is an idiot.A lot of doctors are still lulled by low numbers; it used to be that any PSA below 4 was considered “safe.”That’s not true.
[Tweet “The key is, is your PSA going up, and if so, how fast? #prostatecancer”]
What if You Don’t Have a Baseline?
What if this is your first PSA test?Says Walsh:“If you are in your 40s, 50s, or 60s and you have never had a PSA test, if you get one and your level is greater than 2.5 ng/ml and you can expect to live at least another 15 to 20 years, you should have a biopsy.If your biopsy finds no cancer, you should continue to have your PSA level rechecked at regular intervals, using both the total PSA level and the speed at which it rises over time to determine whether and when you need to have a repeat biopsy.”
When Can You Stop Screening?
That’s a good question.Again, your PSA track record determines a lot.In his research, Bal Carter showed that if PSA testing were discontinued at age 65 in men who had PSA levels below 0.5-1.0 ng/ml, it would be unlikely that prostate cancer would be missed later in life.A more recent study suggested that it is safe to discontinue PSA testing for men aged 75-80 with PSA levels lower than 3 ng/ml.However, the men aged 75-80 who had PSA levels greater than 3 remained at risk of developing life-threatening disease. This also depends on your general health.If you are in your seventies, you don’t have any other health problems and can expect to live a good long life, for your own peace of mind you may prefer to keep on getting tested.
In the Case of PSA, Numbers Really Matter
If PSA is so important, why do you need the rectal exam?Because the PSA test is not foolproof.About 25 percent of men who turn out to have prostate cancer have a low PSA level — say it’s 1.2, and it goes up a little over time, maybe to 1.8 — one that, despite an increase, doesn’t get flagged as suspicious.For several reasons, including the way some tumors make PSA, you need a “back-up” plan (I admit, pun intended). Conversely, the rectal exam is not perfect, either.In many men with prostate cancer, the tumor may be in an inopportune spot, just out of finger’s reach, where it simply can’t be felt by a doctor.In other men, cancer is “multifocal”– there are several patches of cancer, not just one – and the prostate feels uniform in consistency.It’s deceptive, but the doctor’s finger doesn’t have a microscope on it and doesn’t always know when it’s being fooled.Most normal prostates feel soft.Cancer feels hard.But if it’s in several places, or too small to feel yet – even though it’s growing and dangerous – a doctor could touch it and not know.
This is why you need both tests, instead of an either-or approach for early detection.It’s like using the breast exam and mammogram together to find breast cancer in women.In one study of 2,634 men, investigators found that the PSA test and the digital rectal exam were nearly equal in cancer-detecting ability – but they didn’t always find the same tumors.So if only one technique had been used, some cancers would have been missed.Together, these two tests make a formidable team.
Really Important Things You Need to Know Before the PSA Test That Your Doctor Might Not Tell You
Don’t ejaculate for at least two days before you have your blood drawn.This can raise your PSA level, throw off the test, and scare everyone unnecessarily.
Whatever you do, make sure to have the test before the rectal exam.(The rectal exam can stimulate the prostate and cause more PSA to show up in the bloodstream and again, make your PSA level seem higher.)I tell you this because my husband once had the test before the exam, it made his PSA number higher, and we got scared.His doctor should have known better.
If you are taking Proscar or Avodart for BPH, or Propecia for hair loss, all of these drugs lower PSA. They can make it seem artificially low, and if you have cancer, it might be missed.(To correct for this, if you have recently started taking one of these drugs, your PSA level should be multiplied by 2.0.If you have been taking it for five years or longer, your level should be multiplied by 2.5.)
If you have had surgery or a laser procedure to treat BPH, this can make your PSA much lower.Don’t focus on the number; watch what it does.If your PSA begins to increase steadily, you should see a urologist.
If your PSA test shows a significant increase, repeat the test in the same lab.In 25 percent of these cases, the reading will be back down to its former level.Says Walsh:“If there is a clear-cut elevation, ask your doctor about prescribing antibiotics to rule out a possible infection.Often, men receive ciprofloxacin or levofloxacin for three to four weeks and have the PSA measured again.If it is elevated again, you should have a biopsy, using a different antibiotic when you have this procedure, to avoid infection from resistant bacteria.”
In addition to thebook,I have written about this story and much more about prostate cancer on the Prostate Cancer Foundation’s website, pcf.org. The stories I’ve written are under the categories, “Understanding Prostate Cancer,” and “For Patients.” As Patrick Walsh and I have said for years in ourbooks,Knowledge is power: Saving your life may start with you going to the doctor, and knowing the right questions to ask. I hope all men will put prostate cancer on their radar. Get a baseline PSA blood test in your early 40s, and if you are of African descent, or if cancer and/or prostate cancer runs in your family, you need to be screened regularly for the disease. Many doctors don’t do this, so it’s up to you to ask for it.
https://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.png00Janethttps://vitaljake.com/wp-content/uploads/2017/05/vital-jake-logo3-300x146.pngJanet2015-07-29 07:17:232019-06-21 09:39:45Prostate Cancer Screening and You
Walsh is the senior author of a recent Johns Hopkins study that looked at high-risk prostate cancer in older men. The study’s interdisciplinary group of investigators also includes first authors Jeffrey Tosoian and Ridwan Alam, and Carol Gergis; Amol Narang, Noura Radwan, Scott Robertson, Todd McNutt, Ashley Ross, Danny Song, Theodore Deweese, and Phuoc Tran. 
A new blood test called the Cascade Genetic Test looks for mutations in several known “bad apple” genes.
An important study, led by Fred Hutchinson Cancer Research Center medical oncologist Peter Nelson, M.D., funded in part by the Prostate Cancer Foundation, and published in the New England Journal of Medicine, is changing how we think about prostate cancer. What Nelson has found can be summed up like this: 
So don’t despair.
“There’s no one way to select candidates for active surveillance,” says urologist and molecular biologist Chris Barbieri, M.D., Ph.D., of Weill Cornell Medical College/New York Presbyterian Hospital. In addition to doing molecular research on prostate cancer, he treats men with all kinds of prostate cancer and works with several hundred patients currently on active surveillance.
Can men live with slow-growing, low-volume prostate cancer?
You will also have to live your life knowing you have cancer.
Once you know what you’re dealing with, your first reaction should not be, “Oh, my God! I’ve got to get this out of here!” or other words to that effect.
Good news for people who love barbecue, hot dogs, burgers, and steak cooked on the grill: It pays to eat your veggies.
There is a twist to the story: Food safety pays off, too. 